![]() Mild cognitive impairment (MCI), a pre-clinical stage of Alzheimer’s disease, is characterized by cognitive declines that exceed those of healthy aging ( Park, 2020). ![]() Furthermore, the mHbO in the PFC during the VDST was identified to be significantly correlated to the MoCA-K scores.ĭiscussion: These findings shed new light on the feasibility and superiority of fNIRS-derived neural biomarker for screening MCI. Specially, the mean of HbO (mHbO) in the left PFC showed the highest discriminant power for MCI, which was higher than that of the Korean version of montreal cognitive assessment (MoCA-K) widely used as a screening tool for MCI. Results: Findings revealed that significant reductions in HbO concentration were observed in the PFC in the MCI group. The concentration changes of oxy-hemoglobin (HbO) were explored during the task in subject groups. Methods: This study evaluated biomarkers for screening MCI by performing a verbal digit span task (VDST) using functional near-infrared spectroscopy (fNIRS) to measure signals from the prefrontal cortex (PFC) from a group of 84 healthy controls and 52 subjects with MCI. Recently, the potential of biomarker for MCI has gained a lot of attention due to a relatively low discriminant power of clinical screening tools. Although prior studies on MCI screening have been conducted, the optimized detection way remain unclear yet. Introduction: Early detection of mild cognitive impairment (MCI), a pre-clinical stage of Alzheimer’s disease (AD), has been highlighted as it could be beneficial to prevent progression to AD. Department of Occupational Therapy, College of Medical Science, Soonchunhyang University, Asan, Republic of Korea.
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